This website is for US residents only.

Investigational Therapy for Type 1 Diabetes

The UPWARD Study is looking for individuals living with type 1 diabetes (T1D) to participate in a study of an investigational cell-based therapy. The investigational therapy consists of cells designed to produce insulin contained within devices designed to protect the cells from the immune system. These investigational devices are implanted in the space behind the muscles of the abdominal wall. Researchers are studying the safety, tolerability, and effectiveness of the investigational therapy in adults with T1D and are looking to see if it could potentially reduce or eliminate the need for individuals with T1D to take insulin.

See if you may qualify

This clinical study is currently enrolling adults between the ages of 18 and 65 who have type 1 diabetes and require insulin via injections or pump to manage their diabetes. If you are interested in taking part in this clinical research study, please continue below and complete the questionnaire to determine if you are a good candidate and eligible for participation.

Learn more about this clinical study.

See If You May Qualify

*Indicates required field.

Step 1 of 3

By answering the following prescreening questions, you agree to provide your information to Praxis, a service provider of the sponsor of this study, Vertex Pharmaceuticals Incorporated (Vertex). The categories of information collected via this questionnaire include: your name and contact information, information about your health and lifestyle, and any other information that you provide. Your information will be used only to determine whether you are eligible for this research study and, if you consent, to inform you of potential Vertex research studies in the future. It will not be shared with Vertex in any way that could identify you. You will also have the option to delete the information after you complete the prescreener.

If your answers to the questionnaire indicate you may be eligible for the study and you elect to share your contact information, Praxis (we) will share your information with myTomorrows, who is also a service provider to Vertex on this study, and a representative will contact you to do further screening. Based on the results of that screening, and with your permission, your information would be shared with a research site. We will not share your personal information with anyone outside of this study other than as required by law, and we will not sell personal information collected from you as part of this study screening. If you are not found to be eligible for this study, you will have the option for Praxis to keep your information on file for a period of time that you elect so you can be contacted if the eligibility criteria change for the UPWARD Study or if you are potentially eligible for future Vertex studies.

For a fuller description of Vertex’s privacy practices, and of your privacy rights if you are a California resident, please see Vertex’s privacy notice.

If you have a question or want to exercise your privacy rights detailed in the above privacy notice, please contact Praxis at legal@gopraxis.com, as Vertex will not receive your identifiable information.

I agree to the use and sharing of my personal information for the purpose of determining my eligibility for the UPWARD Study and as described above.*

Yes

I agree to the use and sharing of my personal information for the purpose of determining my eligibility for the UPWARD Study and as described above.*

What is your zip code? e.g., 12345* We need to gather this information to determine the research site closest to you.

e.g., 12345

What is your year of birth?yyyy*

YYYY

This website uses Secure Socket Layer technology and encryption methods to protect personal health information.

Step 2 of 3

Have you been diagnosed with type 1 diabetes?*

Yes

Have you been taking insulin for five years or more?*

Yes

Please select your blood type below.*

O negative or positive

A negative or positive

B negative or positive

AB negative or positive

Unsure

Have you ever experienced episodes of severe low blood sugar (hypoglycemia) in which you were unable to treat yourself and someone else had to help you?* (e.g., confusion, uncontrollable behavior, irrational behavior, unusual difficulty in awakening, seizure, loss of consciousness, or memory loss)

Yes

Unsure

Do you currently use, or have you used, tobacco or nicotine-containing products (e.g., nicotine gum, electronic cigarettes) within the last six months?*

Yes

Was your last HbA1c less than 9.5%?*

Yes

Unsure

Please provide your height and weight to assist in calculating your BMI.*

Height in feet

Height in inches

Weight in pounds

Have you ever had an islet cell transplant, an organ transplant, or cell therapy?*

Yes

Unsure

By submitting this questionnaire, you understand that your information will be used and shared as previously described.

This website uses Secure Socket Layer technology and encryption methods to protect personal health information.

For a fuller description of Vertex’s privacy practices, and of your privacy rights if you are a California resident, please see Vertex’s privacy notice.